Cembranoids and their analogues have been reported to have various biological activities such as anti-cancer, anti-bacterial, anti-inflammation, anti-diabetic, neurological activity, anti-fouling, toxicity to brine shrimp, immunosuppressant, anti-Alzheimer’s, anti-oxidant, repellent activity against Sitophilus zeamais, and acetylcholinesterase (AChE) inhibition activity. This evidence concerns the gene ACHE and cancer.