PIAS1 and brain neoplasm: G3 cluster is enriched in interactions of the ABC transporter, ABCA3, suspected to be involved in chemoresistance in brain tumor progression (Hadjipanayis and Van Meir 2009); the dystrophin-glycoprotein SGCB; the SUMO ligase PIAS1, which increases the activity of Gli proteins on the Hedgehog pathway (Niewiadomski et al., 2019); and the heat shock protein DNAJB5, which regulates histone deacetylase (HDAC) nuclear shuttling, whose inhibition is considered to be a promising therapy in MB (Becher 2019).