This multi-layered data set revealed players involved in neuroblastoma cell differentiation and identified roles for signaling proteins insulin-like growth factor 1 receptor (IGF1R), SH2 domain-containing protein tyrosine phosphatase-2 (SHP-2) and cyclin-dependent kinase 16 (CDK16) in Cbl-dependent regulation of neuroblastoma cell function. The gene discussed is PTPN11; the disease is neuroblastoma.