PTPN11 and neuroblastoma: To examine whether the regulatory role of Cbl and Cbl-b observed in SH-SY5Y could be relevant to neuroblastoma in general, we depleted Cbl and Cbl-b in two other neuroblastoma cell lines, Kelly and NBL-S, to assess the effects on protein levels of CDK16, SHP-2, and IGF1R as well as the effects on ERK phosphorylation and neurite outgrowth.