We have previously identified a role for Cbl-b as a negative regulator of NGF-TrkA signaling in neuroblastoma cells and found that depletion of Cbl and Cbl-b was associated with induction of neurite outgrowth, a morphological marker of neuroblastoma differentiation (Emdal et al., 2015). This evidence concerns the gene CBLB and neuroblastoma.