MYO7A and deafness: In the Myosin motor domain, the highest number of missense mutations (28 out of 77) result in US1, followed by 19 in USH1B, 14 in deafness, 13 in hearing loss, 2 in the US, 1 each in keloid formation, LCA, and the US2 Just like in the Myosin motor domain, the highest number of missense mutations result in US1 in the MyTH1 and MyTH2 domains, while in the IQ repeats/coiled-coil region, FERM1, and FERM2 domains, the highest number of missense mutations associate with USH1B disease phenotype.