In another study, Cheng et al. (43) demonstrated that MALAT1 expression is upregulated in the myocardium in DCM mice, and knockdown of MALAT1 obviously alleviates hyperglycemia induced cardiomyocyte apoptosis through releasing miR-181a-5p and regulating the p53-p21 pathway. Here, MALAT1 is linked to familial dilated cardiomyopathy.