MAPT and Alzheimer disease: CK1δ may contribute to the aggregation of hyperphosphorylated tau inclusions (Li et al., 2004) and associates with NFTs in several neurodegenerative diseases, such as AD (Ghoshal et al., 1999; Schwab et al., 2000) PD, PSP, and PiD (Schwab et al., 2000).