Among the dementia patients studied by Schwab et al. (2000), CK1δ did not associate with tau-negative pathogenic inclusions (e.g., Lewy bodies, Marinesco bodies) of non-tauopathy neurodegenerative diseases, whereas it had variable immunostaining intensity amongst dystrophic neurites, NFTs, and neuropil threads in AD brains (Schwab et al., 2000). This evidence concerns the gene MAPT and neurodegenerative disease.