Consistent perturbations of entrainment can lead to “circadian desynchrony,” a misalignment of the circadian clock with the external environment that is associated with an increased risk of numerous diseases and disorders such as cancer, diabetes, and Alzheimer’s disease (AD) (Sahar and Sassone-Corsi, 2009; Bass and Takahashi, 2010; Musiek and Holtzman, 2016; Logan and McClung, 2019). The gene discussed is CLOCK; the disease is Alzheimer disease.