Here, 6-hydroxydopamine (6-OHDA), a potent neurotoxin that destroys dopaminergic and noradrenergic neurons, induced a PD-like phenotype, which caused an increase in levels of acetylated SIRT1 and BMAL1, decreased Per and Cry expression, and an alteration of neuronal antioxidant activity (Wang et al., 2018). This evidence concerns the gene PER1 and Parkinson disease.