BMAL1 and Parkinson disease: Here, 6-hydroxydopamine (6-OHDA), a potent neurotoxin that destroys dopaminergic and noradrenergic neurons, induced a PD-like phenotype, which caused an increase in levels of acetylated SIRT1 and BMAL1, decreased Per and Cry expression, and an alteration of neuronal antioxidant activity (Wang et al., 2018).