TLR9 and systemic lupus erythematosus: Wen et al. showed that TRAF6 rs5030472 and IRF5 rs2004640 gene polymorphisms may be related to SLE susceptibility in the Guangxi Zhuang population, while the TLR9 rs352140 gene polymorphism may be associated with SLE susceptibility in the Guangxi Han population, which suggested that ethnic differences existed (28).