Previous studies have shown that PACAP and its receptors are widely distributed in brain tissues, and that PACAP plays a neuroprotective role in neurodegenerative diseases such as stroke (Matsumoto et al., 2016), traumatic brain injury (Toth et al., 2020), Alzheimer’s disease (Han et al., 2014), and Parkinson’s disease (Wang et al., 2008). This evidence concerns the gene ADCYAP1 and early-onset autosomal dominant Alzheimer disease.