Some studies have demonstrated that CAFs secrete SDF-1 in the tumor microenvironment of various cancers, including pancreatic carcinoma (Wei et al., 2018; Broekgaarden et al., 2019), colorectal cancer (Peng et al., 2018; Kasashima et al., 2021), and lung cancer (Zhu et al., 2017; Shen et al., 2020). The gene discussed is CXCL12; the disease is neoplasm.