In this study, the analysis of TCGA database revealed that the mRNA expression level of SULF2 in the HCC tissues was significantly and positively correlated with that of CAF biomarkers, including ACTA2, FAP, and POSTN. This indicated that SULF2 was positively correlated with CAF differentiation in the HCC microenvironment. Here, SULF2 is linked to hepatocellular carcinoma.