In this study, the analysis of TCGA database revealed that the mRNA expression level of SULF2 in the HCC tissues was significantly and positively correlated with that of CAF biomarkers, including ACTA2, FAP, and POSTN. This indicated that SULF2 was positively correlated with CAF differentiation in the HCC microenvironment. The gene discussed is ACTA2; the disease is hepatocellular carcinoma.