Meanwhile, SHP plays an important role in metabolic diseases (Ding et al., 2015), including hyperlipidemia, diabetes, and liver fibrosis (Weiskirchen and Tacke, 2015), and SHP–/– mice have a higher incidence of spontaneous HCC (Zhang et al., 2008). The gene discussed is NR0B2; the disease is hepatocellular carcinoma.