In addition to its role in liver regeneration and inflammation, FXR also regulates tumorigenesis and proliferation of hepatocellular carcinoma (HCC) (Huang et al., 2015), pancreatic cancer (Giaginis et al., 2015), and gastric cancer (Duan and Fang, 2014). The gene discussed is NR1H4; the disease is hepatocellular carcinoma.