However, differently from what suggested in the paper, there is not the strategy to promote the production of serum and sIgA in patients with Selective IgA deficiency, nor it is possible to use other therapeutic strategies, such as the use of convalescent plasma, in that, in patients who lack IgA there is a contraindication for the use of plasma for possible adverse reactions. This evidence concerns the gene CD79A and selective IgA deficiency disease.