In our study, the NGS-based analysis of patients from Xuanwei with NSCLC revealed their comprehensive and unique profile of genomic alterations; uncommon EGFR mutations, mainly including G719X, S768I, and L861Q, were the predominant EGFR mutation types in the Xuanwei cohort, forming a distinctive subgroup of NSCLC globally. Here, EGFR is linked to non-small cell lung carcinoma.