FOXC2 and neoplasm: FOXC2 has also been linked to angiogenesis—both in the context of normal development and tumor progression—through its ability to transcriptionally regulate genes encoding pro-angiogenic factors including OPN [30], VEGF-A [31], ITGB-3 [32, 33], HEY-2 [33], PDGF-β [34], DLL-4 [32, 33], CXCR-4 [32], and ANG-2 [35].