While functional impacts of CPAP accumulation under tumor progression and inflammation need to be investigated in the future, our observations that loss of CPAP in OSCC cells causes increased EGFR levels and signaling, and enhanced EMT and tumorigenic properties suggest that this microtubule/tubulin interacting protein negatively regulates the EMT process, perhaps by promoting EGFR homeostasis. This evidence concerns the gene EGFR and neoplasm.