To interrogate the impact of mutations, in key oncogenes KRAS and KEAP1 and tumor suppressors TP53 and STK11 that underly a large fraction of undruggable NSCLC, on LP-184 sensitivity, we compared mean LP-184 IC50 between subsets of wild type and mutant cell lines for the individual genes. This evidence concerns the gene KEAP1 and non-small cell lung carcinoma.