The distribution of “intrinsic” breast cancer subtypes (basing on HR and HER2 status) in our cohort revealed that most patients were luminal A (31.6%) and a significant trend was noted when comparing the three age groups (P=0.025), indeed, young and intermediate age patients were most likely to be luminal A subtype whereas the aged patients (over 55 years) seems to have a bad prognostic since they presented a highest proportion of triple negative BC ́s (TNBC ́s) phenotype as indicated in Table 1. The gene discussed is ERBB2; the disease is breast cancer.