MYORG and JAM2 are two causative genes for autosomal recessive PFBC (Yao et al., 2018; Cen et al., 2020; Schottlaender et al., 2020), expressed mainly in astrocytes (ACs) and ECs, which are the fundamental NVU components (Vanlandewijck et al., 2018). The gene discussed is JAM2; the disease is bilateral striopallidodentate calcinosis.