Patients with SLC20A2 mutations are more susceptible to movement disorders, cognitive impairments, and psychiatric symptoms, especially parkinsonism and memory problems, compared with patients with PFBC caused by other gene mutations (Nicolas et al., 2013a, 2015; Donzuso et al., 2019; Grangeon et al., 2019). This evidence concerns the gene SLC20A2 and Cognitive impairment.