PDGFB and bilateral striopallidodentate calcinosis: Mutations in any of these genes that disrupt PDGFB–PDGFRB signaling are another genetic cause of idiopathic brain calcification, although BBB and NVU impairments are inconclusive for PFBC pathophysiology (Keller et al., 2013; Nicolas et al., 2013b; Villasenor et al., 2017; Jensen et al., 2018).