Our method identified a mix of genes that had previously been identified in AD GWAS including <i>APOE</i>, <i>TOMM40</i>, and <i>NECTIN2</i>(<i>PVRL2</i>) and several others that have not been identified in AD genetic studies, but play integral roles in AD-effected functional pathways including <i>IQSEC1</i>, <i>PFN1</i>, and <i>PAK2</i>. This evidence concerns the gene APOE and Alzheimer disease.