Nie et al. (2020) identified a receptor-like protein RE02 (also known as NbCSPR) that recognizes VmE02 in N. benthamiana. However, RE02 (NbCSPR) is a Solanaceae-specific receptor-like protein, and there is no obvious homolog in A. thaliana, Solanum lycopersicum, or Malus domestica. In this study, we identified a novel small secreted protein CcSSP1 from necrotrophic C. carunculoides, which activated host SA signaling and inhibited JA signaling to promote infection, possibly by targeting the conserved and critical protein PR1. Here, TMEM37 is linked to infection.