TSC22D3 and nephritis: Despite this, glomerular immune complex deposition was not detectably increased in the absence of GILZ, suggesting that the effect of dysregulated BCR signaling in the absence of Lyn is a strong enough lesion in B cells that the absence of GILZ does not further exacerbate it and that effects on immune complex deposition do not explain worsened nephritis in the absence of GILZ.