It has been demonstrated that splenomegaly is an IL-6-dependent phenotype in Lyn-deficient mice (20), however increases in IL-6 in Lyn-/- mice were not further exacerbated in the absence of GILZ and mRNA expression of GILZ and IL-6 were significantly positively correlated in human SLE. This evidence concerns the gene TSC22D3 and systemic lupus erythematosus.