Recent studies reveal that those with controlled HIV infection possess long-lived, self-renewing memory stem cell-like CD8+ T cells (TSCM) for the maintenance of functional immunity (37, 38), and suggest that follicular homing CXCR5+ CD8+ T cells are effectively involved in the control of HIV and SIV infections in animal models (39, 40). This evidence concerns the gene CXCR5 and HIV infectious disease.