CD8A and neoplasm: Transforming Growth Factor beta-induced (TGFβi) protein, also named βig-h3, is able to modulate cell adhesion through various integrins, including αvβ3, α1β1, and αvβ5.This glycoprotein is increased during pancreatic cancer and acts either directly on tumor CD8+ T cells by reducing their proliferation and activation or on tumor cells by promoting their migration and invasion (69, 115).