Among the small proteoglycans which are mainly expressed by TME, testican acts as a pro-tumoral molecule by affecting collagen deposition and thus favoring tumor cell growth and invasion, therefore leading to a poor patient survival, whereas lumican interferes with tumor progression and is associated with prolonged patient survival by limiting cancer cell growth and metastasis (50, 52, 53). The gene discussed is SPOCK1; the disease is neoplasm.