INS and polycystic ovary syndrome: At the very beginning, studies on inositol in PCOS management were mostly influenced by metabolic considerations, given that D-Chiro-Ins is required to allow insulin transduction (44) It should be recalled that myo-Ins epimerization into D-Chiro-Ins is under the control of insulin, which tightly modulate the conversion rate according to the tissues needs (45).