Conversely, restoring D-Chiro-Ins levels proved to be beneficial in ameliorating diabetes-related metabolic features, and in reducing the insulin stimulation upon theca cells and, hence, the consequent insulin-dependent enhancement of androgenesis (49), given that insulin-dependent stimulation of ovarian epimerase will be appreciably tempered upon D-Chiro-Ins supplementation. The gene discussed is INS; the disease is diabetes mellitus.