Noticeably, while D-Chiro-Ins inhibits aromatase as previously recalled, myo-Ins seems to enhance aromatase synthesis in granulosa as well as in endocrine-responsive breast cancer, probably acting also through a direct genomic modulation, given that in breast cancer cell the observed increase in aromatase is independent from FSH stimulation (26). This evidence concerns the gene CYP19A1 and breast carcinoma.