A case-control study of obese and overweigh children with and without NAFLD showed a significantly higher fasting glucose, insulin, total cholesterol, low-density lipoprotein cholesterol (LDL-c), triglycerides, systolic blood pressure and diastolic blood pressure, and lower HDL-c in children with NAFLD (52). This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.