MAPT and Alzheimer disease: In the total AD subtypes, Spearman rank correlation tests revealed that the CSF levels of Aβ1-38, Aβ1-40, Aβ1-42, P-Tau and T-Tau were significantly negatively correlated with the amounts of lobar CMBs (r = −0.274, p = 0.004; r = −0.216, p = 0.019; r = −0.193, p = 0.049; r = −0.298, p = 0.0016; r = −0.331, p = 0.0005, respectively, by Spearman's rank correlation t-tests), while the CSF levels of NFL were significantly positively correlated with the number of lobar CMBs (r = +0.397, p < 0.0001: Spearman t-test), although YKL-40 showed no significant difference (Figures 3A–G).