We found that CSF levels of NFL were significantly higher in lvPPA than those of other AD subtypes after controlling for multiple comparison, additionally, CSF NFL elevated by the increased number of lobar CMBs in lvPPA patients, presumably that lobar CMBs and/or CAA pathology in lvPPA might involve secondary and/or indirectly neuronal and axonal degeneration based upon AD pathology. The gene discussed is NEFL; the disease is Alzheimer disease.