CHI3L1 and Alzheimer disease: We calculated diagnostic values of the CSF biomarkers of Aβ1-42 (cut off <308.7), P-Tau (cut off > 47.43), T-Tau (cut off > 270.2), NFL (cut off > 858.8), and YKL-40 (cut off > 78.59) by the data from the typical AD (EOAD and LOAD) patients (n = 72) and non-dementia (ND) subjects (n = 33).