In the last 14 years our research group has described the mediating role of the p21Ras family isoforms in fibroblast biology (Martínez-Salgado et al., 2006, 2008; Fuentes-Calvo et al., 2012, 2013; Ucero et al., 2013; Muñoz-Félix et al., 2016) and in renal fibrosis in vivo (Grande et al., 2010). This evidence concerns the gene HRAS and renal fibrosis.