We assayed GSH, GSH/GSSG, GPx, SOD and MDA, which are important markers in lipid peroxidation and found that rosiglitazone (an ACSL4-specific inhibitor) inhibited a decrease in GPx activity, GSH levels and GSH/GSSG ratio after cerebral ischemia, indicating its inhibitory effect on lipid peroxidation. The gene discussed is SOD1; the disease is brain ischemia.