Therefore, P2X7 receptor modulation has proven to be a promising option for treatment of neurodegenerative diseases and antagonists of this receptor have shown to slow deposition of the amyloid plaque and progression of AD disease in animal model systems (Diaz-Hernandez et al., 2012; Rodrigues et al., 2015). The gene discussed is P2RX7; the disease is neurodegenerative disease.