Increased level of P2X7 receptor expression has been detected on microglia (Yiangou et al., 2006), astrocytes (Narcisse et al., 2005), and oligodendrocytes (Matute et al., 2007) of the post-mortem multiple sclerosis patients (Narcisse et al., 2005; Grygorowicz et al., 2010; Burnstock, 2015; Sadovnick et al., 2017). Here, P2RX7 is linked to multiple sclerosis.