Motor and memory deficit induced by 6-hydroxydopamine (6-OHDA) animal model of PD was ameliorated by administration of selective P2X7 receptor antagonists (Marcellino et al., 2010; Carmo et al., 2014; Ferrazoli et al., 2017; Kumar et al., 2017), suggesting P2X7 receptor play a pro-inflammatory role in microglia activation in PD (Kumar et al., 2017). Here, P2RX7 is linked to Parkinson disease.