SOD1 and temporal lobe epilepsy: Brain penetrable.  Blocked the Bz-ATP induced IL-1β release.  Attenuated amphetamine-induced hyperactivity.  Efficacious in rat model of neuropathic pain.  Reduced temporal lobe epilepsy.  Produced long-lasting delay in kindling development.  Chronic administration to SOD mice model of ALS modified disease progression in female animals, but had no effect in male animals.