SOD1 and amyotrophic lateral sclerosis: Increased expression of P2X7Rs has been detected in microglia (D'ambrosi et al., 2009; Rudnick et al., 2017) or astrocytes (Gandelman et al., 2010; Apolloni et al., 2014) isolated from superoxide dismutase 1 (SOD1G93A) mouse model of ALS, and application of the P2X7R antagonist BBG improved spinal cord pathology and ameliorated the disease in these mice (Apolloni et al., 2014; Bartlett et al., 2017).