Brain penetrable.  Blocked the Bz-ATP induced IL-1β release.  Attenuated amphetamine-induced hyperactivity.  Efficacious in rat model of neuropathic pain.  Reduced temporal lobe epilepsy.  Produced long-lasting delay in kindling development.  Chronic administration to SOD mice model of ALS modified disease progression in female animals, but had no effect in male animals. This evidence concerns the gene IL1B and amyotrophic lateral sclerosis.