P2RX4 and amyotrophic lateral sclerosis: Several members of the purinergic receptors, specifically play major roles in CNS disorders including: Alzheimer's disease (AD), Parkinson disease (PD), Huntington's disease (HD), Frontotemporal dementia (FD), Amyotrophic Lateral Sclerosis (ALS), Multiple Scleroses (MS), Traumatic Brain Injury (TBI), stroke, cerebral ischemia, epilepsy, psychiatric diseases, sleep disorder, and neuropathic pain (Burnstock, 2008, 2016; Tozaki-Saitoh et al., 2011; Beamer et al., 2016).