P2X7 receptor activation by ATP followed by NLRP3 induced IL-1β release that results in neuroinflammation are major contributors of neuropsychiatric disorders, especially depression (Adinolfi et al., 2018; Bhattacharya and Jones, 2018; Franklin et al., 2018; Li and Barres, 2018; Liu et al., 2018). Here, IL1B is linked to major depressive disorder.