Several members of the purinergic receptors, specifically play major roles in CNS disorders including: Alzheimer's disease (AD), Parkinson disease (PD), Huntington's disease (HD), Frontotemporal dementia (FD), Amyotrophic Lateral Sclerosis (ALS), Multiple Scleroses (MS), Traumatic Brain Injury (TBI), stroke, cerebral ischemia, epilepsy, psychiatric diseases, sleep disorder, and neuropathic pain (Burnstock, 2008, 2016; Tozaki-Saitoh et al., 2011; Beamer et al., 2016). The gene discussed is P2RX7; the disease is amyotrophic lateral sclerosis.