Additionally, P2X7 receptor deficient microglia was not activated with Aβ (Sanz et al., 2009); P2X7 receptor silencing enhanced microglia phagocytosis and clearance of Aβ (Ni et al., 2013); and receptor deficiency reduced Aβ plaque, improve synaptic plasticity and resulted in reduction of cognitive deficits in AD mice model (Chen et al., 2014). The gene discussed is P2RX7; the disease is Alzheimer disease.