P2RX7 and Huntington disease: Brains of Tet/HD94 and R6/1 mice, which are genetic models of HD, have shown increased mRNA and protein levels of P2X7 receptor (Diaz-Hernandez et al., 2009), and BBG has shown to prevent loss of body weight and motor coordination deterioration in the R6/1 mouse model of HD (Diaz-Hernandez et al., 2009).