Moreover, reactive astrocytes can undergo morphological changes and upregulate the production of glial fibrillary acidic proteins (GFAP) [11] and promote the release of inflammatory mediators such as cytokines (interleukin (IL)-1b and IL-6) and tumour necrosis factor-alpha [22], thereby triggering/promoting neuroinflammation as observed in AD [16, 17, 23, 24]. This evidence concerns the gene GFAP and Alzheimer disease.