MAPT and Alzheimer disease: Our immunostaining and autoradiography studies using 3H-Deprenyl have highlighted tight interconnection between tau pathology and reactive astrogliosis by demonstrating similar laminar cortical distribution for AT8 (tau) and GFAP antibody staining as well as for 3H-THK5117 and 3H-DED radiotracers in AD cases [39], including carriers of Arctic mutation in the amyloid-β precursor protein (AβPParc) [40].