Thereafter, we identified five potential target genes, NETO2, SLC15A4, ENO2, ALDOA, and KDM3A. Among them, histone demethylase KDM3A is an important epigenetic modifier that is reportedly involved in tumor progression in multiple cancers, while miR-335 has a single, highly conserved, predicted target site with the 3-UTR of KDM3A (Fig. 2A). This evidence concerns the gene ENO2 and neoplasm.