STING1 and neoplasm: Activation of the STING pathway occurs by DNA recognition by cyclic guanosine monophosphate synthetase (cGAS) resulting in the generation of the cyclic dinucleotide (CDN) STING ligand 2′3′ cGAMP and is required for the generation of tumor-specific T cell responses, representing one mechanism of immune surveillance in the TME5.