PTGFRN and neoplasm: Although the precise mechanism of CDN delivery to the cytosol of the APC and the role of PTGFRN in mediating exoSTING potency is yet to be established, these data suggest that glycoprotein PTGFRN on EVs may play a role in maximizing activation of immune cells and in vivo anti-tumor activity, which may be contributed by cellular tropism and immune cell signaling activity of PTGFRN17,34.