TARDBP and amyotrophic lateral sclerosis: Yamanaka and colleagues reported that the mutants exhibited longer half-lives than WT TDP-43 and speculated that the longer half-lives of these mutant proteins were correlated with accelerated ALS onset55; G348C and A382T mutants belong to the longest half-life group among 7 disease causing mutants (G298S, A315T, M337V, Q343R, G348C, N352S and A382T).