LMNA mutations have been observed in many diseases that also belong to the identified cluster, including the Heart-hand syndrome (Slovenian type)90, lipodystrophy associated with mandibuloacral dysplasia91, the Charcot-Marie-Tooth disease, type 2B192, LMNA-related muscular distrophy, and different cardiac diseases caused by LMNA mutations93. This evidence concerns the gene LMNA and heart-hand syndrome.