Aligned with these observations, our analysis of tyrosine phosphorylated HER3 (pHER3, HER3 phosphorylated in Tyr1289) in the HNSCC TCGA dataset demonstrated a significantly lower overall survival (OS) in patients harboring high levels of pHER3 (Fig. 1d), suggesting pHER3 was a strong predictor of poor prognosis. Here, ERBB3 is linked to head and neck squamous cell carcinoma.