Indeed, CD8 T cell depletion abolished the response to anti-PD-1, as we recently reported30; but in the case of anti-HER3, all mice had an initial response to HER3i followed by a rapid tumor regrowth (Supplementary Fig. 10), contrasting the prolonged response achieved in most immunocompetent mice (Fig. 6a). Here, ERBB3 is linked to neoplasm.