For example, the murine monoclonal antibody against the cryptic domain adjacent to human fibronectin EDB, BC-1 was fused with murine IL12 (huBC-1-mIL-12) and showed inhibitory effects on various kinds of cancer xenografts in immunocompetent severe combined immune deficiency mice, including colon cancer, skin tumor, and prostate cancer468,469. This evidence concerns the gene FN1 and cancer.