For example, CD44v6 expression in diffuse large B-cell lymphoma (DLBCL) correlates with advanced disease stage, and coexpression of any of the CD44 isoforms with RHAMM could identify a subgroup of DLBCL patients with a very poor prognosis independent of the International Prognostic Index537. This evidence concerns the gene HMMR and diffuse large B-cell lymphoma.