Notably, individuals with mutations in the RNase H2 complex, consisting of RNASEH2A, RNASEH2B, and RNASEH2C, show clinical pathologies that resemble those observed in TREX1 mutated patients, including aberrant type I IFN signaling along with AGS and systemic lupus erythematosus. The gene discussed is TREX1; the disease is Aicardi-Goutieres syndrome.