In particular, the actions of the structure-specific endonuclease MUS81 can bring about the accumulation of cytosolic DNA via MUS81-dependent cleavage of stalled replication forks, leading to cGAS/STING activation and induction of type I IFNs, as observed in various prostate cancer cell lines (Ho et al. 2016). Here, MUS81 is linked to prostate cancer.