IFNA1 and ovarian carcinoma: Two independent reports showed that treatment of colorectal and ovarian carcinoma cells with low doses of the demethylating agent 5-aza-2′-deoxycytidine (5-aza) led to the accumulation of dsRNAs and subsequent activation of the IFN response (Chiappinelli et al. 2015; Roulois et al. 2015).