As presented in Table 3, adding NT-proBNP to traditional risk factors showed a significant improvement of the risk prediction for MACEs, with the C-index rising from 0.666 to 0.702 in patients with pre-DM (p = 0.018) and from 0.676 to 0.711 in patients with DM (p = 0.020). This evidence concerns the gene NPPB and diabetes mellitus.