TLR3 and Zika virus infectious disease: Intriguingly, Dang et al. found that Toll-like-receptor 3 (TLR3), which has been associated with neurodegeneration and neuroinflammation, was upregulated in organoids after ZIKV infection and that severe cell apoptosis and size shrinkage in ZIKV-treated organoids were relieved after treatment with a TLR3 competitive inhibitor [103, 104].