TMED9 and neoplasm: In addition to TMED9 expression (hazard ratio (HR), 1.463; p = 0.047), the tumor size (HR, 1.543; p = 0.023), portal vein invasion (HR, 3.463; p < 0.001), and hepatic vein invasion (HR, 3.971; p < 0.001) were all shown to have adverse impacts on OS (Table 4).