Moreover, transcriptome sequencing in the hypothalamus of pigs with high or low FCR revealed that genes involved in the thyroid hormone signalling pathway (TRH, PIK3CG, PLCD4, PRKCG), thyroid hormone synthesis (ADCY1, ADCY7, ADCY8, GPX3, PRKCG, TSHR) and autoimmune thyroid disease (SLA-DMB, SLA-DMA) were differentially expressed [39]. Here, ADCY8 is linked to autoimmune thyroid disease.