Moreover, transcriptome sequencing in the hypothalamus of pigs with high or low FCR revealed that genes involved in the thyroid hormone signalling pathway (TRH, PIK3CG, PLCD4, PRKCG), thyroid hormone synthesis (ADCY1, ADCY7, ADCY8, GPX3, PRKCG, TSHR) and autoimmune thyroid disease (SLA-DMB, SLA-DMA) were differentially expressed [39]. The gene discussed is GPX3; the disease is autoimmune thyroid disease.