Such data include the following: (1) the occurrence of cardiac M2Mφ robustly increases post-hAM-MSC-dressing therapy in the wide area of the heart; (2) the profile of upregulated reparative genes post-hAM-MSC-dressing therapy, i.e., IL-10, CXCL12, IGF1, and TGFB1, closely corresponds to that in cardiac M2Mφ reported;38 and (3) M2Mφ play a critical role in post-MI cardiac repair, and forced augmentation of M2Mφ by IL-4-based treatment or adopted transfer results in enhanced myocardial repair post-MI in mice.32 This evidence concerns the gene IGF1 and myocardial infarction.