GSTM1 and anemia (phenotype): Data coming from animal experimental models suggest that extreme hemodilution is well tolerated until Hb concentrations fall to 30 or 50g/L, when depressed left ventricular function and ischemic electrocardiographic changes occur, respectively.(34) Similar results were obtained in resting healthy volunteers subjected to acute isovolemic hemodilution up to Hb concentrations of 50g/L,(35) suggesting a good tolerance to hemodilution anemia in a wide range of Hb levels.