Adult hospitalized patients with confirmed SARS-CoV-2 infectionMore than 3 days of symptoms related to COVID-19Computed tomography (or chest X-ray) with COVID-19 alterationsNeed for oxygen supplementation to keep SpO2 > 93%, or need for mechanical ventilation for less than 24 hours before the randomizationAt least two of the following inflammatory tests above the cutoff: D-dimer > 1,000ng/mL, C-reactive protein > 5mg/dL, Ferritin > 300mg/dL, Lactate dehydrogenase > upper-level limit. The gene discussed is CRP; the disease is COVID-19.