Although variations exist between OFs from different patients with TAO in the levels of IGF-1 secretion, SSTR2 expression, and NF-κB activity, OFs from patients with TAO consistently showed higher levels of IGF-1 secretion, SSTR2 expression, and NF-κB activity compared to controls, in the basal status without any treatment, even after five passages in vitro after separation from orbital tissues. This evidence concerns the gene IGF1 and thromboangiitis obliterans.