The M2-macrophage plays a role during parasitic, helminthic, and fungal infections and reveal expression for CD64 and CD209, a C-type lectin and induce secretion of IL-13, CCL1, CCL2, CCL13, CCL14, CCL17, CCL18, CCL22, CCL23, CCL24, CCL26, IL-8, monocyte chemo-attractant protein-1 (MCP)-1, IP-10, macrophages inflammatory protein (MIP)-1β, and CCL5 (RANTES). This evidence concerns the gene CCL4 and fungal infectious disease.