glycogen synthase kinase-3β (GSK-3β), hexokinase 2 (HK-2), sterol regulatory element-binding protein 1c (SREBP-1c), and carnitine palmitoyltransferase I (CPT-1) were detected to explore the possibility and mechanism of Ato in the treatment of PAH. Here, GSK3B is linked to pulmonary arterial hypertension.