Similarly, Wu et al. showed that high expression of TYROBP, a gene closely related to immune cell infiltration and co-expressed with programmed cell death protein-1 (PD-1) and cytotoxic T lymphocyte–associated antigen-4 (CTLA-4), was associated with low survival rates in ccRCC [14]. This evidence concerns the gene PDCD1 and nonpapillary renal cell carcinoma.