PPARGC1B and Sepsis: Moreover, lipopolysaccharide has been reported to regulate the myocardial expression of the FAO enzyme and oxidation rates by deactivating the kinetic response of the PGC-1 axis, which is associated with systemic inflammation and sepsis-induced by LPS stimulation (Beutler and Rietschel 2003; Rossi et al. 2007; Puigserver et al. 2001; Feingold et al. 2004).