The optimal model in DLBCL is the combination of 7 marker genes, including LIPF, CCDC144B, PRO2964, PHF1, SFTPA2, NTS, and HP (Figure 4B and 4G), which had the highest AUC of 0.951 (Figure 4E). Here, SFTPA2 is linked to diffuse large B-cell lymphoma.